Frank Lampard knocked old boss Jose Mourinho out of the EFL Cup as Derby County beat Manchester United on penalties, while Burton Albion triumphed against Burnley.
Marouane Fellaini's late equaliser took Tuesday's tie to a shootout following a 2-2 draw at Old Trafford, with Scott Carson saving Phil Jones' poor penalty to complete a dramatic 8-7 success for the Championship side.
Harry Wilson and Jack Marriott had earlier struck for the Rams as Lampard enjoyed a memorable reunion with Mourinho, his manager at Chelsea.
United's rivals Manchester City made short work of League One side Oxford United as the holders progressed to the fourth round thanks to a 3-0 win.
Phil Foden helped to create goals for Gabriel Jesus and Riyad Mahrez before scoring his first goal for the club to wrap up a star performance.
Yeeeeeeessss @PhilFoden— Fernandinho (@fernandinho) September 25, 2018
Along with United's exit, the other big shock of the day came at Burton, where Burnley's awful cup competitions record under Sean Dyche continued with a 2-1 loss.
Kevin Long's header gave the Premier League team the lead, but League One Burton hit back through Liam Boyce, who then set up Jamie Allen for a late winner.
Penalties were needed in the all-Premier League tie at Molineux, with Danny Ward saving three spot-kicks after a goalless draw to book Leicester City a fourth-round berth at the expense of Wolves.
Go on the Warden Penalty saving masterclass @dan_ward52— James Maddison (@Madders10) September 25, 2018
Callum Wilson scored a 94th-minute winner to secure a 3-2 home victory for Bournemouth against Blackburn Rovers, while Andros Townsend struck twice as Crystal Palace won 3-0 at West Brom.
Jordan Rhodes' hat-trick booked Norwich City's progression with a 4-3 thriller at Wycombe Wanderers, with 15-year-old Harvey Elliott making his Fulham debut in their 3-1 win at Millwall.
Middlesbrough scored all four of their penalties to edge through in a shootout after drawing 2-2 with Preston North End, while Blackpool are in the last 16 after a 2-0 home win against 10-man QPR.
|Essien tells Loftus-Cheek to stay and fight for Chelsea chance|
|Nainggolan relishing challenge of first Milan derby|
|Curry: Slap me if I tire of championship celebrations|
|Sevilla don´t fear Messi or Barca – Kjaer|
|Low: Dropped Muller is still very important for Germany|
|Hayward put ´dark memories´ behind him with Celtics return|
|I hope I´m in Klopp´s good books! - Koeman jokes after resting Wijnaldum|
|Rested Fellaini should be fit for Manchester United, says Martinez|
|France´s mentality must be right - Lloris|
|Bellinger seals dramatic win as Dodgers level up NLCS|
|Curry, Durant lead Warriors past Thunder|
|Kjaer surprised by LaLiga-leading Sevilla as Machin´s men remain grounded|
|A-League preview: Honda the big arrival as fascinating season awaits|
|Mexico 0 Chile 1: Sanchez helps La Roja to late win|
|Celtics too good for 76ers in NBA opener|
|United States 1 Peru 1: Flores salvages late draw for visitors|
|Martinez not worried about Belgium depth|
|Red Sox move ahead of Astros in ALCS|
|Depay ´a joy to watch´, says Koeman|
|Timberwolves owner looking to trade Butler, backs Thibodeau|
|Shepard says Giants have ´total faith´ in Manning|
|Hazard is out of this world – De Ligt enjoys Belgium test|
|Tite: Brazil were better than Argentina|
|Foley eyes World Cup after re-signing with Wallabies, Waratahs|
|Low slams decisive France penalty call|
|I fined him for his goal at Old Trafford! Giggs delighted for Wales hero Wilson|
|Matuidi lauds Deschamps´ tactical nous after Germany win|
|Scaloni excited by Argentina despite Brazil loss|
|Tsonga back in business, Dzumhur dumped out in Moscow|
|Germany suffer six defeats in a year for first time|
|Many clubs have asked about Piatek - agent|
|Bartomeu: Barca open to defensive reinforcements after Vermaelen injury|
|Bonn spoil PAOK´s landmark European game|
|Konta conquers Mertens in Moscow|
|Republic of Ireland 0 Wales 1: Wilson stunner moves Giggs´ side top|
|France 2 Germany 1: Griezmann delivers Low blow as Les Bleus reign in Paris|
|Belgium 1 Netherlands 1: Groeneveld cancels out Mertens strike|
|Argentina 0 Brazil 1: Miranda heads late winner after rivalry fails to ignite|
|Messi would struggle in this Manchester United team – Scholes|
|Falcons place Devonta Freeman on injured reserve|
|Westbrook ruled out of Thunder opener|
|Wilder´s team open to Joshua talks|
|Brentford appoint Thomas Frank as new head coach|
|England´s perfect performance sets the standard - Trippier|
|Odell Beckham Jr. needs to create headlines on the field, says Giants owner|
|Robshaw joins list of England absentees|
|Chile need goals from Sanchez despite United form - Rueda|
|Modric reveals Ronaldo respect, ´will never play with´ Messi|
|Osaka can be one of the greats, says coach Sascha Bajin|
|Liverpool´s Naby Keita carried off injured in Guinea match|
|Duminy to miss Australia tour for shoulder surgery|
|F1 Raceweek: Ferrari ready to ´challenge the impossible´ as Hamilton nears title|
|Umesh replaces injured Thakur in ODI squad|
|IAAF delay implementation of testosterone ruling amid Semenya challenge|
|Fakhar and Sarfraz lead Pakistan recovery after Lyon blitz|
|Japan see off Uruguay in seven-goal thriller|
|Arda Turan given huge fine by Istanbul Basaksehir after alleged brawl with singer|
|Busquets no better or worse than Dier – does Opta data back up Allardyce claim?|
|United boss Mourinho charged for alleged post-match comments by FA|
|Halep withdraws from Kremlin Cup ahead of WTA Finals|
|Renato Sanches eager for further Bayern Munich minutes|
|Nations League standings: Promotion, relegation and race for finals|
|Windies coach Law banned for ´inappropriate comments´ in India Test|
|Carrick denies Manchester United stars are ´not trying´|
|Ferrari struggling under pressure of chasing Mercedes, says Massa|
|Australia desperately need Smith and Warner back - Warne|
|Draxler warns Germany: Mbappe has 300 hp!|
|Draymond Green says Warriors will have to ´bring it´ every night in the West|
|England´s ´wonderful bravery´ leaves Southgate excited for the future|
|Jayasuriya: I always conduct myself with integrity and transparency|