South Africa tightened their grip on the second Test against England thanks to a third day of steady accumulation at Trent Bridge.
Dean Elgar, Hashim Amla and returning captain Faf du Plessis all brought up half-centuries, with the home attack forced to toil for their wickets before the Proteas declared on 343-9.
Alastair Cook had a first-ball lbw dismissal by Morne Morkel overturned on review as England began an improbable attempt at what would be a world-record chase of 474 and, even though he and Keaton Jennings nervily reached one without loss at the close, Joe Root's side are likely to head to The Oval at 1-1 in the four-match series.
After breezing to a 211-run win in his first Test in charge at Lord's, Root has become more attuned to the harsh realities of captaincy in the longest format in Nottingham, with a paltry first-innings effort of 205 leaving England chasing the game.
Opener Elgar and Amla resumed on 75 for one and set about methodically building upon their overnight lead of 205 on a morning of ragged frustration for their opponents.
Elgar, not always the easiest batsman on the eye, passed 50 with a thick outside edge off James Anderson and another nick off Stuart Broad fell safely in the following over.
Broad and England then offered up an error they could ill afford – appealing half-heartedly and neglecting to use a review when replays showed Amla feathered a delivery behind to Jonny Bairstow when on 25.
In Broad's next set of six, new-ball partner Anderson dropped a tough one-handed chance at gully after Elgar slashed at a wide one, but England were rewarded for their persistence with two wickets in as many overs before lunch.
Ben Stokes – who bustled in impressively for his 2-34 – unsettled Elgar with some short stuff and the left-hander appeared to pull out of his stroke as he lobbed a catch to square leg to depart for 80.
Anderson (2-45) was the catcher and he then encouraged the dangerous Quinton de Kock to edge behind.
Amla remained at lunch, having brought up his fifty with a six off Liam Dawson, as he did in the first innings, although the Hampshire all-rounder had South Africa's number three dismissed leg before on review, 13 shy of a century.
Dawson's fellow spinner Moeen Ali was ignored by Root until mid-afternoon but helped himself to 4-78 as South Africa belatedly looked to hit out after reaching tea on 236 for four.
Du Plessis crunched three through the covers off Moeen to raise his bat but saw partner Temba Bavuma continue his struggles against spin by lofting the Worcestershire man to Root at mid-off.
Anderson, Broad and Mark Wood all summoned probing but unrewarding spells with the second new ball before Stokes pinned Du Plessis in front for 63 with one that kept low.
Gary Ballance and Stuart Broad held fine catches as Chris Morris and Keshav Maharaj tried to slog Moeen with the declaration in sight.
Vernon Philander had more success in that regard during a breezy 42 that ended with a caught and bowled for Moeen, although his more decisive work is probably still to come with ball in hand alongside Morkel, who bowled with palpable menace during a gripping end to the day.
|Schauffele wins Tour Championship, Thomas claims FedEx Cup title|
|Axar returns for final two Australia ODIs|
|Guardiola baulks at Chelsea or United fearing in-form Manchester City|
|Morata shining as Chelsea´s leading man after Juve, Madrid frustration|
|Black Caps omit Neesham and Broom for India ODI series|
|CAF Champions League Review: Etoile Sahel see off Al Ahli Tripoli to reach semi-finals|
|Moeen ´just had a slog´ in breathtaking century|
|Seahawks & Titans sit out national anthem|
|President Trump responds to anthem protests: Locked arms is good, kneeling is not acceptable|
|WATCH: Showboating costly as Bears´ Cooper is denied TD|
|Late Isa snatches Toulon win, Lyon up to third|
|Federer secures Laver Cup victory for Europe|
|Dzumhur sees off Fognini for history-making ATP triumph|
|Brighton winner was a foul, claims frustrated Benitez|
|Bjerregaard claims maiden European Tour title at Portugal Masters|
|Steelers skip anthem, players kneel as NFL shows solidarity amid Trump criticism|
|Brutal Moeen century sets up thumping England win|
|India wrap up series win over Australia and regain top spot in ODI rankings|
|Exeter Chiefs cruise to first place, Northampton Saints hammer London Irish|
|Spalletti: Unbeaten Inter must go beyond their limits|
|Brighton and Hove Albion 1 Newcastle United 0: Hemed the hero in second home win|
|Pedrosa unimpressed with incredible Rossi|
|Better late than never - Matuidi delighted with start to life at Juventus|
|Gojowczyk upsets Paire to win maiden ATP title at Moselle Open|
|Mladenovic´s miserable run continues in Wuhan|
|Sensational Sagan storms to third successive World crown|
|Inter 1 Genoa 0: Late D´Ambrosio header snatches victory for Spalletti´s side|
|Delph a willing deputy for injured City left-back Mendy|
|Tom Brady and Aaron Rodgers post messages of ´unity´ as unprecedented NFL Sunday dawns|
|Ravens and Jaguars players kneel, lock arms together for anthem at London game|
|Howedes ruled out for four weeks|
|Milan lacked determination and quality in Samp defeat - Montella|
|Sheffield Wednesday 2 Sheffield United 4: Clarke at the double in derby win|
|Uruguayan Primera Division fixtures cancelled amid referee strike|
|Marquez pulls clear with Aragon win as Rossi claims remarkable fifth|
|Patriots owner Robert Kraft, a Trump ally, ´deeply disappointed´ by president´s tone|
|Billy Vunipola sidelined for four months|
|Mendy hoping to follow successful City season with World Cup triumph|
|Sampdoria 2 AC Milan 0: Duvan Zapata claims family bragging rights|
|Dybala backs dropped Higuain to rediscover clinical touch|
|President Donald Trump continues shots at NFL in Sunday morning tweets|
|WATCH: Injured Rossi survives practice shunt|
|21st century boy - Lyon youngster Geubbels makes Ligue 1 history|
|Jones: England looking for a rookie with X-factor|
|Sensational Kipchoge storms to Berlin victory|
|Napoli fear more knee surgery for Milik|
|Spalletti promises reaction from smarting Inter|
|Beale eyes morale-boosting Bloemfontein win|
|Hughie Fury would wipe the floor with Anthony Joshua, says promoter|
|Montella backs ´fired up´ AC Milan to ´raise the bar´|
|French Open champion Ostapenko seals second career title in Seoul|
|Meunier: PSG don´t have Neymar dependency|
|Brewers claim walk-off win over Cubs|
|Pogba could have surgery on hamstring injury – surgeon|
|Wozniacki ends 2017 drought with Tokyo title|
|MLS Review: Shield-chasing Toronto beaten again, Union extinguish Fire|
|Casey motivated by near-misses in pursuit of glory|
|Kisner takes helicopter from East Lake to Georgia game|
|Spieth adds ´cheerleading´ to game plan as FedEx Cup hopes fade|
|Allegri: Higuain needs to rediscover form after Juve axing|
|Stanton closes in on Maris record with 57th homer|
|Yankees back in postseason after clinching playoff spot|
|Juventus great Nedved comes out of retirement|
|I´ll be back! Schwarzenegger visits Barcelona|
|A future doubles pair? Federer and Nadal say no after memorable clash|
|Are you on loan from Man City? Messi quizzes Girona´s Maffeo|
|Curry responds to Trump uninviting Warriors to White House|
|Casey takes outright lead at Tour Championship|
|ICC launches investigation in Sri Lanka following corruption allegations|
|CAF Champions League Review: Holders Sundowns out on penalties|