Darnell McIntosh crossed twice as in-form Huddersfield Giants shocked St Helens 16-12 in their first game in the Super 8s, while Wigan Warriors held off Castleford Tigers' second-half rally to triumph on Friday.
Saints suffered a surprise Challenge Cup semi-final defeat to Catalans Dragons last weekend and the leaders' 12-match Super League winning run came to a halt at Langtree Park.
Huddersfield laid the foundations for a fifth win a in a row by making a blistering start, taking a 16-0 lead courtesy of a brace from McIntosh and an Alex Mellor try.
Ben Barba - reportedly on his way back to the NRL - made two errors under pressure from towering Danny Brough kicks as the Giants took charge, but he made amends to some extent by going over after Theo Fages and Jonny Lomax combined to set him up.
Luke Thompson crossed for a converted score midway through the second half, but the Giants held on.
Wigan saw off Castleford 24-22 in a week when it was announced that Shaun Edwards will take over as head coach in 2020, with Adrian Lam replacing departing boss Shaun Wane next season.
The Warriors were in cruise control with a 20-0 lead at half-time, Liam Marshall, Gabe Hamlin, Dan Sarginson and Ryan Sutton going over.
Jake Trueman, James Clare, Paul McShane and Mitch Clark crossed for the Tigers after the break, but penalties from Morgan Escare and Sam Tomkins proved to be the difference between the sides.
Tom Lineham scored a hat-trick as 10-try Warrington Wolves thumped Catalans Dragons 56-6 in a dress rehearsal for the Challenge Cup final, while Wakefield Trinity saw off out-of-sorts Hull FC 31-13.
Salford Red Devils were 28-10 winners at Hull KR in the Qualifiers.
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